4-Methyl-4-pentenoic acid
4-Pentenoic acid, 4-methyl-
CAS: 1001-75-8
Molecular Formula: C6H10O2
4-Methyl-4-pentenoic acid - Names and Identifiers
| Name | 4-Pentenoic acid, 4-methyl- |
| Synonyms | 4-Methyl-4-pentenoic acid 4-Pentenoic acid, 4-methyl- |
| CAS | 1001-75-8 |
4-Methyl-4-pentenoic acid - Physico-chemical Properties
| Molecular Formula | C6H10O2 |
| Molar Mass | 114.14 |
| Density | 0.974 |
| Boling Point | 199℃ |
| Flash Point | 96℃ |
| Storage Condition | 2-8°C |
4-Methyl-4-pentenoic acid - Reference Information
| application | 4-methyl -4-pentenoic acid can be used as an intermediate in pharmaceutical synthesis and an intermediate in organic synthesis, mainly used in laboratory research and development and chemical pharmaceutical synthesis. |
| Preparation | The preparation of 4-methyl-4-pentenoic acid is as follows: Step 1.4-methyl-pent-4-enoic acid ethyl ester synthesis. LiHMDS(1.0M solution, 8.4mL,8.4mmol) was added to room temperature solution of methyl triphenylphosphonium iodide (3.00g,7.38mmol) in THF(25mL). After 15min, the solution was cooled to -35 ℃, and ethyl levulinate (1.mL,7.05mmol) was added. Remove the cooling bath and stir the reaction for 40min, then quench with water and extract twice with EtOAc. Combine organic layers, wash with water and brine, dry (Na2SO4), and concentrate in vacuum. The crude product was purified by flash chromatography on silica gel (3% EtOAc/hexane). step 2.4-methyl-pen-4-enoic acid synthesis. 1NNaOH(10mL) was added to EtOH(5mL) solution of ethyl 4-methyl-pen-4-enoic acid (530mg,3.73mmol). The mixture was stirred for 3 days, concentrated in vacuum to remove ethanol, and diluted with H2O and Et2O. Separate the layers and wash the organic layer once with water. The water layers were combined, acidified to pH1 with 1NHCl and extracted twice with Et2O. The organic layers were combined, washed with brine, dried (Na2SO4), and concentrated in vacuum to produce 4-methyl-4-pentenoic acid. |
Last Update：2024-04-09 20:52:54
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View History
4-Methyl-4-pentenoic acid
1,3-苯二硫酚
Evacetrapib (LY2484595)
异戊酸-顺-3-己烯酯
YTTERBIUM(III) NITRATE N-HYDRATE
Benzaldehyde, 4-(acetyloxy)-3-hydroxy- (9CI)
pentaflurobenzyl cyanide
D-二苯甲酰酒石酸酐
1,3-苯二硫酚
Evacetrapib (LY2484595)
异戊酸-顺-3-己烯酯
YTTERBIUM(III) NITRATE N-HYDRATE
Benzaldehyde, 4-(acetyloxy)-3-hydroxy- (9CI)
pentaflurobenzyl cyanide
D-二苯甲酰酒石酸酐